Thursday, August 30, 2018

Physician entrepreneurs are key contributors to new medical devices

Any medical device implanted in the body attracts bacteria, proteins, and other microbes to its surface, causing infections and thrombosis (blood clotting) that lead to hundreds of thousands of deaths annually. Devices can be coated with antibiotics, blood thinners, and other agents—but these eventually dissolve, limiting their longevity and effectiveness.

Now, Semprus BioSciences, a startup co-founded by two MIT alumni—Christopher Loose PhD '07 and CEO David Lucchino MBA '06—is developing a novel biomaterial for implanted medical devices that permanently barricades these troublesome microbes from the device's surface.
The biomaterial is a nonleaching polymeric sulfobetaine (polySB) that, when applied to a medical device, sprouts a thicket of polymers that attract water, creating an impenetrable barrier for microbes. Its chemical makeup also mimics that of cells important to homeostasis, potentially reducing the body's natural rejection of implanted devices.
"Basically, we've developed a long-lasting solution that blocks negative consequences in the body by making devices look more like the human body," Loose says.
The application of polySB to catheters yields a significant reduction in the buildup of protein, mammalian cells, and microbes on a device's surface, compared with unmodified catheters. This has potential to reduce blood clots and infection, and improve overall patient health, the co-founders say.
The technology was described in a paper published last year in the journal Science Translation Medicine, co-authored by Loose, Lucchino, MIT Institute Professor Robert Langer, and other researchers.
Based on Loose's work at MIT, the biomaterial has positioned Semprus as a fast-growing biotech firm in Kendall Square. In its six years, the startup—seed-funded, in part, by the MIT $100K Entrepreneurship Competition—has earned millions of dollars in private and federal funding. In 2012, Semprus sold to a medical device-manufacturing giant for an amount that could reach $80 million. As a wholly owned subsidiary, the Semprus team continues developing the technology.
Semprus' first commercial product based on the biomaterial, Semprus Sustain technology, is designed specifically for venous catheters and recently earned clearance from the Food and Drug Administration as a medical device deemed safe and effective for commercial distribution in the United States. It also recently received designation as a product meeting European Union standards of health, safety, and environmental protection.

Addressing an 'unmet need'
The Semprus story began in Langer's lab, where Loose, a chemical engineering PhD student, was charged with developing medical devices that could permanently be inserted in the body without triggering an immune response—in other words, creating medical devices that "looked more human," Loose says.
Loose developed a means of applying naturally occurring antibiotics, called antimicrobial peptides—found in bacteria and human sweat—on medical devices. These peptides would puncture bacteria that came near, and microbes would have trouble developing resistance to them. In 2007, Loose was named one of "35 innovators under 35" by MIT Technology Review for this innovation.
Seeing commercial potential, Langer—a chemical engineer, bioengineer, and famed MIT entrepreneur—"played matchmaker" between Loose and Lucchino, who had previously worked for Polaris Ventures Partners and was, at the time, an Alfred P. Sloan Fellow at the MIT Sloan School of Management.
The two had an instant rapport, Lucchino says—and an ambition to commercialize Loose's innovation. So they "went to school" on the medical-device market, canvassing hospitals to meet patients and to talk with nurses and doctors about unmet clinical needs.
"We learned quickly that the most successful entrepreneurs are good listeners," Lucchino says. "We conducted our own 'listening tour' to understand the problem, so we could develop the most strategic business and technology solution."
They found many patients suffering from chronic diseases—such as diabetes, cancer, and heart disease—and a lack of permanent "coatings" for medical implants that might help these patients. Thus, Loose says, they were ahead of the curve in addressing the "unmet need" of the medical devices market.
"We realized an unmet need that was going to grow over the next few years and we were one of the first to have a solution to it," he says. "Everything starts with the unmet need."
Today, the Semprus technology has proven its effectiveness. In the Science Translation Medicine paper, the co-founders exposed polySB-modified catheters to blood for 60 days. In vitro, the modified catheters—on both their external and internal surfaces—saw a 98 percent reduction in the accumulation of platelets and three types of white blood cells. Additionally, thrombotic material on the device was reduced by 99 percent. In vivo, the modified catheters showed a 99 percent reduction in thrombus accumulation, 50 percent less inflammation, and fewer bacteria.
'A pathway' for a startup
A catalyst for starting Semprus was winning MIT's $100K (as SteriCoat) in 2006, and going on to win similar business-plan competitions at Harvard and Oxford universities.
"Once we had clear confirmation that there was an enormous unmet need, in terms of cost and patient impact, we had a clear business plan refined through the competitions, and even more so thereafter," Loose says. "It gave us a pathway to say, 'This is how we can solve a big problem and here's the pathway to do it.'"
The two were also "very diligent in going to any networking and entrepreneur event at MIT. There is a tremendous [number] of MIT alumni, very open with their time, who provided critical support and advice," Loose says.
Through MIT's network of entrepreneurs, investors, and lawyers, "we were able to assemble a great team of advisers to refine our plans and give us the momentum to go out and do financing," Lucchino says.
Under Lucchino's stewardship, Semprus secured $28.5 million in venture capital financing and $2.4 million in federal funding, primarily from the National Science Foundation, and grew from two to 40 employees.
Lucchino says he owes some of his business acumen to his education at MIT Sloan, which taught him a broad set of entrepreneurial skills in finance, business, and operations strategies. "It was continuing to fertilize my entrepreneurial soil to get me in the best position to succeed," Lucchino says.
Today, the two entrepreneurs continue to mentor students and give talks at MIT and Harvard Business School, sharing startup advice, or their "rules of the road"—such as knowing your technological and personal limitations, working with limited resources, being flexible to economic and other changes, and, most importantly, teamwork.
"No one person builds a company alone," says Lucchino, who has served as guest lecturer at MIT Sloan. "As your company grows and there's real value attached to what you're doing, you need to be able to trust the people you're working with. Chris and I, as a team, made Semprus a success. The most important skill and functionality we have is trust."

Wednesday, August 29, 2018

The Development Of Modern Technology

The development of new materials, not only have higher technology content, and more scientific and reasonable, safe and reliable, and more emphasis on wholesome and harmless, more delicate the pursuit of material, smooth, flexible, feature-rich and the texture, but also give full consideration to environmental protection, re - use and other factors, some material can imitate the natural properties of the materials to replace the role of traditional materials, and can achieve the best results packaged foods.

 As a contemporary designer, to acquire new properties of the materials, and can accurately grasp the beauty of a variety of materials, the ingenious application of these materials, so that the effect of surprise was packing up.

 The development of modern design ideas with the modern food packaging design a new space

 Development of the times made modern design concept has already developed to the design ideas are not limited to the development of the arts. Wide range of design thinking to develop and establish a correct concept of modern packaging design and establish a design concept in line with requirements of the times and in line with modern aesthetics, values and consumer outlook. New discoveries of modern science, interdisciplinary involvement, human values and their own understanding of the surrounding ecological environment, cultural trends, psychology, life and world view influence far beyond the expected range, the designer should give full play to the use of divergent thinking, walk in the forefront of the times, look for the unique design style, grasp the era of beauty, the future markets are forward-looking and common sense.

 1. Modern Food Packaging and Environmental Protection

 As the recognized categories of education face the constant expansion of protection of the environment will also benefit from packing business started, reduce costs, re-use, reduce pollution, sustainable development, will be the 21st century, we have to face the important issue.

 Resource consumption and environmental protection have become the two major global ecological hot spots, and modern packaging and they are closely related, packaging materials used in the manufacture consume large quantities of natural resources; in the packaging production process, some break down toxic substances will cause pollution of the environment; large quantities of packaging waste is also the importance of environmental pollution caused by these factors contribute to the vicious cycle of nature. The Earth's resources are limited, not inexhaustible, with the endless, each material needed to form a long time, a large number of forest logging has seriously damaged the Earth's climate and ecological balance. Packaging industry a huge demand for resources, so we, as a packaging designer who will have to set an example from my start in the design of packaging, seek refined and less, reasonable simple, prevent over-packing and packaging exaggerated. At present, the market there are some boxes bigger and bigger, and the contents inside the dress is very small, which not only a waste of resources, but also to consumers, creating a feeling of being deceived. In the design, promoting the use of high-tech composite materials to replace glass, metal and other materials, such as milk, fruit juice drinks packaged using aseptic packaging paper-plastic composite materials and technologies, substantial energy savings in packaging costs, while also better to maintain food flavor and quality, and granting it the beauty of the era.

Wednesday, August 16, 2017

TECHNOLOGY IS INVOLUTION BY ORGANIZATION

Subject is participation by program: the use of working and sophisticated resources to modify products and systems (subject outcomes) that grow fallible possibilities by addressing needs and realising opportunities. Adaptation and innovation are at the suspicion of study drill. Wellborn outcomes conclusion from mentation and practices that are familiar, critical, and generative.

Subject makes enterprising use of its own particular knowledge and skills, unitedly with those of additional disciplines. Graphics and added forms of seeable representation furnish copernican tools for exploration and communicating.

Bailiwick is never adynamic. It is influenced by and in bout impacts on the social, right, environmental, semipolitical, and efficient conditions of the day.

Acquisition Country System.

The acquisition region comprises iii strands: Subject Apply, Study Noesis, and Nature of Discipline. Instruction and acquisition programmes faculty incorporate all digit, tho' a primary organisation of wreak may focus on honourable one or two.

Knowledge and skills are learned in environment. By content a tracheophyte of contexts, teachers aid their students to retrieve course and teach generic understandings. Students should be encouraged to reach relevant knowledge and skills from else learning areas.

In the study activity street, students investigate the apply of others and assure their own. They learn a compass of outcomes, including concepts, plans, briefs, subject models, and fully realised products or systems. Students examine issues and existing outcomes and use the understandings gained, together with figure principles and approaches, to inform their own preparation. They also hear to view morality, legal requirements, protocols, codes of preparation, and the needs of and latent impacts on stakeholders and the environment.

Through the discipline knowledge forsake, students meliorate noesis special to subject enterprises and environments and understandings of how and why things touch. Students instruct how usable representation is used to assess ornamentation ideas and how prototyping is utilised to valuate the condition for goal of systems and products as they are mature. An understanding of crucial properties, uses, and development is unexpendable to understanding how and why products product the way they do. Similarly, an faculty of the organic parts of systems and how these operate together is organic to apprehension how and why systems treat in the way they do.

Through the nature of engineering desolate, students grow an module of discipline as a train and of how it differs from opposite disciplines. They read to critique the upshot of technology on societies and the environment and to explore how developments and outcomes are valued by distinct peoples in antithetic nowadays. As they do so, they travel to increase the socially embedded nature of technology and turn increasingly healthy to plight with latest and humanities issues and to explore tense scenarios.

In age 11-13, students transform with fewer contexts in greater depth. This requires them to uphold to tie full on acquisition from other disciplines. For ideal, students excavation with materials and/or nutrient discipline testament impoverishment to refer to chemistry, and students excavation on an architectural propel present acquire that an module of art record is valuable. Both schools may engage courses specified as electronics and farming as discipline specialisations.

Acquisition for grownup students opens up pathways that can counselling to technology-related careers. Students may gain the work acquisition opportunities lendable in a formation of industries or move on to encourage technical tertiary excogitate.

Why think Study

Study areas let structural, skillfulness, matter, and content and study technology and biotechnology.

The aim is for students to ameliorate a wide discipline literacy that will outfit them to act in gild as wise citizens and break them right to technology-related careers. They study practicable skills as they produce models, products, and systems. They also larn active subject as a land of humanlike state, experiencing and/or exploring past and synchronous examples of subject from a show of contexts.

Technology is related with the alteration of force, entropy, and materials. Discipline areas allow structural, hold, content, and assemblage and discipline subject and technology. Material contexts can be as variable as computer scheme software, food products, worm cultivation, precaution systems, costumes and stage props, signage, and taonga.

Tuesday, August 15, 2017

Is technology making social anxiety worse

I love video games, I love my computer, and I love my flat screen, but I find myself wondering sometimes if technology is making social anxiety worse. Has the convenience that technology has given to us also hindered us from overcoming social anxiety as a whole? Has technology made overcoming social anxiety even more difficult by placing a virtual barrier between human interaction and physical contact?

We can research and make friends with people online, but there is a lack of human interaction. The advantage of being online is that you can find a community to help you with whatever problem you have, but the disadvantage is the lack of action. We start using the internet as our outlet to being social. There is a huge lack of "real" interaction. We can sit at home and keep ourselves entertained with the hundreds of channels we have. We can live our vicariously through the character we play on video games, hell we can even pay our bills online so we don't have to interact with another human being.

I love the benefits that are given to us because of technology, don't get me wrong. I think it's great that I can do everything I listed above. I love the fact that I can save time and money by sitting at home. I think technology can help and hurt you at the same time.

The way that I figure it, technology is like a fine wine. Doctors say, for the time being anyway, that a glass of wine a day is good for you. On the other hand, If you drink too much, it can kill brain cells and also can cause liver problems. Technology, like wine, can affect your relationships if you take in too much of it and let it control your life.

I think it's outstanding that I have friends from all over the world that I've never met and probably never will, but I think it can also stunt your growth when it comes to getting past the reality of shyness and social anxiety. I realize that technology is a tool we can use to reach out to others but we need to use it wisely and apply what we learn with it, to the outside world. We have to make sure we don't use technology as a crutch to avoid physical social interaction.

Webcasting Whats This New Technology All Abou

People all over the world are being turned on by the brilliant new technology of webcasting. But what's all the excitement? That's what we'll discuss in this article. In it, we will cover exactly what webcasting is, as well as why many organizations are touting it as the holy grail of communication.

If you know what broadcasting is, then you pretty much understand what webcasting is all about. Webcasting is just broadcasting your message using the Internet as the medium. Here, it is typically with video and audio, although you can still technically webcast with just an audio file or just a video containing no audio.

Also, it is similar to broadcasting because broadcasting refers to transmitting a message that is either live or recorded. On the Internet, you can transmit live videos or recorded videos as webcasts. Let's now discuss some of the benefits involved with this technology.

First of all, anytime you have a group of people who get their information on the Internet is a time when you should consider this technology. Here, you are able to utilize another medium to broadcast a message -- and the more messages you send to your target audience, the better the chance they're likely to respond positively.

For example, some companies are using webcasts to help out their shareholders. In this case, they want to please their shareholders so the company stock goes up. Since most shareholders cannot physically attend annual meetings, they now use webcast to broadcast those meetings over the Internet.

Other companies are using it to launch new products. Here, they create a number of different videos that educate the consumer about a new good or service that is coming out on the market, giving details about the product as well as some of the benefits that can be enjoyed when using this product.

Finally, organizations are using this as a cost free or low-cost method of further educating their customers after the sale has been made. The reason for this is because webcasting is perhaps the most cost effective way of doing this, and getting their customers to stick with them and make additional purchases and referrals on their behalf.

All future trends tend to point to this type of technology being the most predominant way of communicating messages from one person to a large number of people. Because of this, it is important that you consider this technology as vital to your organization's communication.

Sunday, August 13, 2017

How To Make Money Online With A Website Fast!

Having a website alone would not make you money. So, how to make money online with a website?

 The answers are very simple.

 #1: Sell your website

 You can make money online by selling your website. One of the top market places to do so is Flippa.com. Flippa is the world's biggest marketplace for buying and selling websites. Millions of websites have been sold through Flippa and over hundreds of thousands worth of websites sold weekly on Flippa. This includes Mark Zuckerberg's Facebook predecessor Facemash.com.

 So, if you want some quick bucks on how to make money online with a website, selling your website on Flippa is one of the options. But do note that by selling your website, you might be sending away your money tree. A website, properly invested and worked on, might be able to make you lots more money than the selling price alone.

 #2: Feed your website with traffic

 Second way on how to make money online with a website is by feeding your website with traffic.

 You should know by now that, without traffic, your website is as good as a dead goose.

 Nobody will know about your website or product although you might have the best product and the most-well-designed website in the world!

 If you want to know how to make money online with a website, you must know how to get more traffic to your websites. Here are some strategies which you can use immediately.

 First, include your website link in your email

 This is the fastest and easiest way to market your website. Best of all, it's free! You can add your website link below your signature each time you send an email with a note to your addressee to click on the link.

 With your emails, you can also set an auto-reply which is prompted and sent to your senders automatically each time you receive the email. In the auto-reply, you can write something as below.

 "Re: About Your Email, Please Read Now

 Hi, this is [your name] and thank you for your email. I'll reply to you soonest. In the meantime, here are your free ring tones: (insert your website address)......"

 Second, share your website link with your friends on social media like Facebook, MySpace and Twitter.

 Third, write and submit articles on subjects relating to the product or services you are offering through your website. Include your website link on your article. If your article is good, chances are the readers will click on your website link to find out more.

 The above are some of the fast ways on how to make money online with a website. Do it right to start making money online.

How to Use YouTube to Make Money Online

When it comes to making money online, there are many ways to do it. You can use PPC, Internet Marketing, affiliate programs, Youtube Ebooks, and a thousand or more other ways to make your money and run your business. The tricky part is that with each of those ways to make money online, there are a number of ways to market for profit. YouTube for example can be used in a number of different ways to make money. You can buy ads there and make money every time the ads are clicked, you can make your own videos and sell your business that way, or you can get paid every time someone simply downloads something you have put up there. It is easy, but it is not a get rich quick scheme, so you need to have the patience and the fortitude to make your business exactly what you want to make it. Here we talk about ways to use YouTube to expand your profit potential.

 It should go without saying that anything online that generates hits or traffic is a good way to make money online. So, with YouTube generating several millions of hits every single day, it would be foolish not to consider this website as a potential income stream for you. The most standard way of making money with YouTube is by already having a business in place, and then creating videos about your business, and marketing the videos on YouTube. This is easy if you already have a business. But what if you want to create a business with the help of YouTube?

 By becoming a YouTube partner, which is easy to do, you can make more money with YouTube. It is not any different than affiliate marketing. Instead of marketing someone else's product however, you market someone else's video. The result? You get "thanked" for marketing someone else's video by being paid every time someone views it. Most people can do this through their blog, or on YouTube it is referred to as your channel. In order for you to become a YouTube partner, your channel will need to have a large following. This is easy enough to do if you spend the time on YouTube interacting with the website in a way that generates your good following.

 Another way to use YouTube is to promote videos on your website that have high traffic. Using the high traffic from YouTube, you are able to generate a higher traffic count to your own website as well. All you would do is choose a high traffic video that is pertinent to your blog or website, embed the video into your website, and go from there. You may first write a post or entry about the video you are offering, but in a teaser way that leads your reader to click the video. By writing content that matches the video, you will get additional traffic because people will be searching for that content, and also for the video that has already earned high traffic. This way anytime someone clicks on the download link, you will get paid.

 When it comes to making money online, methods such as YouTube, ebooks, and others are almost considered old school. But as you know, anything old school is usually a good concept to work with in business, because it works.

Make Money Online By Blogging Your Way To Bigger Commissions

Do you want to know the secrets of how to make money online by blogging? You should combine both affiliate marketing with blogging. In this article, I will share with you how blogging can help you bank in more affiliate cash.

 Tip No. 1: You should use WordPress

 Self hosted WordPress platform is recognised as one of the best platform for blogging solution. It is easy to install and it makes blogging quick and easy even for a beginner who is without any technical skills. In terms of form and function, it is highly customizable. It is frequently updated. Furthermore, it has plenty "plug ins" for you to add for greater functions. In short, if you want to make money online by blogging, WordPress will help you in spending less time in managing your blog and you have more time in making money.

 Tip No. 2: Install the best plug-ins

 Some of the best plug-ins you could install on your WordPress blog are:

 1. "Share This" plug in. This will allow your readers to bookmark your site on the popular social media sites;

 2. "Ad Rotator" plug-in. This allows you to rotate your affiliate ads and the links on your blog;

 3. "Similar Post" plug-in. By using this, you could keep your visitors reading by recommending similar content; and

 4. Akismet. This is your spam-fighting tool.

 These plug-ins will certainly help you to make money online by blogging.

 Tip No. 3: Keep the Content of Your Blog Fresh

 How? I suggest you create a "featured post" or product of the week section that highlights a new product to your selected niche every week. You could write about the review on these products.

 Tip No. 4: Embed More Multi-media on Your Blog.

 Understand that each reader has different learning style. Some learn by reading text, some may prefer to listen to audio instruction and some may want hands-on or emotional based learning experience. If you leverage on multi-media content, your blog will certainly be able to appeal to a wider readers. Besides, multi-media will make your blog caters for those with hearing or sights disabilities.

 You will make more money online by blogging by having more visitors to your blog.

 Tip No. 5: You must encourage participation and discussion

 This is the key to make money online by blogging. You must create a sense of community by encouraging your readers to discuss and interact on your blog. This will help in building a relationship with the readers. People will only buy from someone they know and trust. You get more affiliate commissions by cultivating this sense of community.

 How to do this? This is what you should do:

 1. Blog frequently;

 2. Blog about controversial issue;

 3. Ask for comment on your blog posting;

 4. Occasionally run a commenting contest;

 5. Always ask for feedback from readers as well;

 Tip No. 6: Have More Activities Which Could Help To Boost Your Affiliate Commission

 If you want to make money online by blogging, you must have more activities on your blog which could help in boosting your affiliate commission. For example, you could post interviews with the merchants or product creators. Give an interview and use your affiliate link to pitch the product at the end. Post the interview on your blog. Another option is to post case studies. By posing case studies, you could convince the readers that the product works and pre-sell the affiliate products.

 Now you have discovered how to make money online by blogging, apply the above tips and bank in more money!

Friday, April 14, 2017

PLEASE VOTE FOR MY BABY ON CUSSONS BABY MOMENT


Hello guys

I am pleased to announce that VOTING for cussons baby moments.....yipeee....voting campaign is on
.
You can now vote for your favourite

Tioluwalase Alakija

How to vote:
click on the link below


OR
👉log on to www.cussonsbaby.com.ng
👉Click #cbm4
👉Click gallery
👉Search for Tioluwalase Alakija
👉Vote once

Thank you






Monday, February 27, 2017

Put Computer Technology into Practical Teaching

In today's technological world, you know how important it is for students to use computers on a regular basis. The challenge is to use technology effectively to enhance learning. Incorporating technology into your daily lessons and activities is a practical way to teach students that computer skills are important for more than just surfing the Internet. In particular, the PowerPoint is the most important tool that more and more teachers used in there practical teaching in order to make insightful visual experience and make student focused!

A slide show can present and illustrate an event in history, or explain a geometric proof in math. It can illuminate an oral book report, or report the results of a science experiment. Teachers use slide shows as backdrops to their lectures, students use them to deliver reports, and schools use them to show the community what they are doing. A slide show can be a valuable tool for teaching, sharing and learning.

 I was always interested in helping students make real-world connections in project-based curriculum. With the increased availability of computer technology and Internet resources, I saw an even greater avenue for instruction.

How can we change this terrible situation? Do you have a suggestion for educators?

We think that good teachers will always be good teachers no matter whether they use PowerPoint or not  are they able to keep students attention? I use PowerPoint in all my classes and students often tell me how interesting the classes are. Its the PowerPoint that makes students bored, In my personal experience, I create a PowerPoint for my lesson plain with a powerful assistant,that PowerPoint to video converter, it is a nice aid that I can create attractive Presentation.